I do I train a 3 year old great dane who destroys the house and pees and poops on the floor?

I recently adopted a 3 year old female great dane. As sweet as she is though, she is very destructive and pees and poops in the house no matter how many times she is let out. Ive given her tons of toys and nothing is working. I need some specific advice on what to do? Ive never had to train an adult dog who weighs as much as I do before.